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EMG and nerve conduction studiesdemonstrate classic myopathic findings, including fi bril-lation potentials, early recruitment, and short-duration,low amplitude polyphasic motor unit potentials. In that two gases withdifferent oxygen concentration, one for the ven-tilator (FiO2 = 0.21) and the other for the CTGIcircuit (FiO2 = 1), have to be used. She remembers being sick all of the time for the past 10 years.According to her husband, she constantly takes medications for all of her ailments.She has visited numerous physicians and none has been able to diagnose her con-dition correctly
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it is increasingly clear that p53 and its ubiquitin ligase Mdm2are also important factors in managing the cellular response to low oxygen levels.Under conditions of cellular stress, such as DNA damage, p53 is induced and actsas a transcription factor to speci?cally target genes involved in cell cycle control andapoptosis.
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It is important to stabilize these patients prior to anesthesia. This result is supported by themodeling studies of Schwardt et al
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